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BDBM393389 3-((4'-Methoxy-5-phenoxy-[1,1'-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile::US9963444, Example 90

SMILES: COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N

InChI Key: InChIKey=IQWAOZKOMILBHW-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393389   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393389
PNG
(3-((4'-Methoxy-5-phenoxy-[1,1'-biphenyl]-2-yl)meth...)
Show SMILES COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N
Show InChI InChI=1S/C24H22N2O3/c1-27-20-10-7-18(8-11-20)24-13-22(29-21-5-3-2-4-6-21)12-9-19(24)16-28-23-14-26(15-23)17-25/h2-13,23H,14-16H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 5.70n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393389
PNG
(3-((4'-Methoxy-5-phenoxy-[1,1'-biphenyl]-2-yl)meth...)
Show SMILES COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N
Show InChI InChI=1S/C24H22N2O3/c1-27-20-10-7-18(8-11-20)24-13-22(29-21-5-3-2-4-6-21)12-9-19(24)16-28-23-14-26(15-23)17-25/h2-13,23H,14-16H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Burnham Institute for Medical Research



Assay Description
In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...

Chem Biol Drug Des 71: 131-9 (2008)


BindingDB Entry DOI: 10.7270/Q2639S2B
More data for this
Ligand-Target Pair