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SMILES: Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1

InChI Key: InChIKey=LCRLHAYDJUFDBS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 396858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM396858 (US9981950, Example 65) Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1 Show InChI InChI=1S/C16H16ClN5/c1-11-8-14(4-5-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-2-3-12/h4-8,10,12H,2-3,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals					Assay Description Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...				Bioorg Med Chem Lett 19: 451-8 (2009) BindingDB Entry DOI: 10.7270/Q2TH8Q1D
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM396858 (US9981950, Example 65) Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1 Show InChI InChI=1S/C16H16ClN5/c1-11-8-14(4-5-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-2-3-12/h4-8,10,12H,2-3,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description TBD				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396858 (US9981950, Example 65) Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1 Show InChI InChI=1S/C16H16ClN5/c1-11-8-14(4-5-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-2-3-12/h4-8,10,12H,2-3,9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair