Found 12 hits for monomerid = 396967 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7... |
J Med Chem 52: 3576-85 (2009)
BindingDB Entry DOI: 10.7270/Q2FB5593 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve... |
J Med Chem 52: 3576-85 (2009)
BindingDB Entry DOI: 10.7270/Q2FB5593 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve... |
J Med Chem 52: 3576-85 (2009)
BindingDB Entry DOI: 10.7270/Q2FB5593 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10442810 (2019)
BindingDB Entry DOI: 10.7270/Q2NG4T17 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10442810 (2019)
BindingDB Entry DOI: 10.7270/Q2NG4T17 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2MW2N2P |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10844069 (2020)
BindingDB Entry DOI: 10.7270/Q2CZ3B73 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10844069 (2020)
BindingDB Entry DOI: 10.7270/Q2CZ3B73 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10844069 (2020)
BindingDB Entry DOI: 10.7270/Q2CZ3B73 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2MW2N2P |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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antibodypedia
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2MW2N2P |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396967
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-22-9-13-24(14-10-22)38-15-1-2-25(31(38)41)30(40)37-23-11-7-20(8-12-23)26-16-27(21-5-3-19(17-33)4-6-21)39-28(26)29(34)35-18-36-39/h1-2,7-16,18-19,21H,3-6H2,(H,37,40)(H2,34,35,36)/t19-,21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10442810 (2019)
BindingDB Entry DOI: 10.7270/Q2NG4T17 |
More data for this
Ligand-Target Pair | |
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