null

SMILES: Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1

InChI Key: InChIKey=FFCKHBSETQPNFE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 396970   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair