null

SMILES: COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12

InChI Key: InChIKey=QEPUHXTUGSVGOF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 396987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair