null

SMILES: Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1

InChI Key: InChIKey=WDXBRUHVKWGDOP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 396991   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair