null

SMILES: CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12

InChI Key: InChIKey=JDLALDLQNPOGIS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 397015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair