null

SMILES: CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12

InChI Key: InChIKey=ICWGNNCQWSWBRG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 397056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397056 (US10442810, Example 119 | US10844069, Example 119 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ncco4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H36N8O4/c1-19(2)34(45)40-13-10-22(11-14-40)27-16-25(29-31(35)37-18-38-42(27)29)21-4-6-23(7-5-21)39-32(44)26-17-41(24-8-9-24)20(3)28(30(26)43)33-36-12-15-46-33/h4-7,12,15-19,22,24H,8-11,13-14H2,1-3H3,(H,39,44)(H2,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair