null

SMILES: CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N

InChI Key: InChIKey=VVGJPTXPAMARLF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 397074   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	US11591338, Example 137 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	US11591338, Example 137 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	US11591338, Example 137 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397074 (US10442810, Example 137 | US10844069, Example 137 ...) Show SMILES CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N Show InChI InChI=1S/C37H38N8O4/c1-4-49-21-32-26(20-38)18-30(37(48)44(32)28-8-6-5-7-9-28)35(46)42-27-12-10-24(11-13-27)29-19-31(45-33(29)34(39)40-22-41-45)25-14-16-43(17-15-25)36(47)23(2)3/h5-13,18-19,22-23,25H,4,14-17,21H2,1-3H3,(H,42,46)(H2,39,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair