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BDBM397396 US9987278, Compound Reference 6

SMILES: CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(OCCNC(=O)C=C)c1

InChI Key: InChIKey=SLXAMJYFWRQZMM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 397396   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
FLT3(D835Y)


(Homo sapiens (Human))		BDBM397396
PNG
(US9987278, Compound Reference 6)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(OCCNC(=O)C=C)c1
Show InChI InChI=1S/C26H31N7O3/c1-3-11-29-24-22(18-31-26(33-24)30-14-10-19-8-12-27-13-9-19)25(35)32-20-6-5-7-21(17-20)36-16-15-28-23(34)4-2/h4-9,12-13,17-18H,2-3,10-11,14-16H2,1H3,(H,28,34)(H,32,35)(H2,29,30,31,33)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair