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SMILES: CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(c1)N(C)C(=O)CNC(=O)C=C

InChI Key: InChIKey=NAELFTPQBUDKEC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 397401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [D835Y]


(Homo sapiens (Human))		BDBM397401
PNG
(US9987278, Compound Reference 11)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(c1)N(C)C(=O)CNC(=O)C=C
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-32-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-20-7-6-8-21(16-20)35(3)24(37)18-31-23(36)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,31,36)(H,33,38)(H2,29,30,32,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair