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BDBM397405 US9987278, Compound Reference 15

SMILES: CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NCCNC(=O)C=C)c1

InChI Key: InChIKey=UHDDRQXPHYDOMV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 397405   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [D835Y]


(Homo sapiens (Human))		BDBM397405
PNG
(US9987278, Compound Reference 15)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NCCNC(=O)C=C)c1
Show InChI InChI=1S/C26H32N8O2/c1-3-11-30-24-22(18-32-26(34-24)31-14-10-19-8-12-27-13-9-19)25(36)33-21-7-5-6-20(17-21)28-15-16-29-23(35)4-2/h4-9,12-13,17-18,28H,2-3,10-11,14-16H2,1H3,(H,29,35)(H,33,36)(H2,30,31,32,34)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair