BDBM398087 4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-5-ylmethyl)-amide::US10323000, Compound 23::US10676433, Compound 23

SMILES: COCCn1cc(C(=O)NCc2cccc3OCCOc23)c2c(Cl)cccc12

InChI Key: InChIKey=ZYDCSFKWUDMBOP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 398087   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM398087 (4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxyli...) Show SMILES COCCn1cc(C(=O)NCc2cccc3OCCOc23)c2c(Cl)cccc12 Show InChI InChI=1S/C21H21ClN2O4/c1-26-9-8-24-13-15(19-16(22)5-3-6-17(19)24)21(25)23-12-14-4-2-7-18-20(14)28-11-10-27-18/h2-7,13H,8-12H2,1H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....				US Patent US10676433 (2020)
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM398087 (4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxyli...) Show SMILES COCCn1cc(C(=O)NCc2cccc3OCCOc23)c2c(Cl)cccc12 Show InChI InChI=1S/C21H21ClN2O4/c1-26-9-8-24-13-15(19-16(22)5-3-6-17(19)24)21(25)23-12-14-4-2-7-18-20(14)28-11-10-27-18/h2-7,13H,8-12H2,1H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Philipps-University Marburg					Assay Description Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....				Bioorg Med Chem 16: 8574-86 (2008) BindingDB Entry DOI: 10.7270/Q26M395S
					More data for this Ligand-Target Pair