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SMILES: CCOc1cc(nc2cc(ccc12)C(=O)NCCc1cncn1C)-c1ccc(F)cc1

InChI Key: InChIKey=AGMDASXGRPCIIA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398265   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398265
PNG
(US10323018, Compound I-2)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCc1cncn1C)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN4O2/c1-3-31-23-13-21(16-4-7-18(25)8-5-16)28-22-12-17(6-9-20(22)23)24(30)27-11-10-19-14-26-15-29(19)2/h4-9,12-15H,3,10-11H2,1-2H3,(H,27,30)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair