BindingDB logo
myBDB logout

null

SMILES: CCCc1nc(nc2cc(ccc12)C(=O)NCc1ccc2nccn2c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=RCMRPBFUXBJKMN-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398274   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398274
PNG
(US10323018, Compound I-8)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCc1ccc2nccn2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H22ClN5O/c1-2-3-22-21-10-7-19(14-23(21)31-25(30-22)18-5-8-20(27)9-6-18)26(33)29-15-17-4-11-24-28-12-13-32(24)16-17/h4-14,16H,2-3,15H2,1H3,(H,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair