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SMILES: COCCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1

InChI Key: InChIKey=RPMMWOOGUMGOAQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398353   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398353
PNG
(US10323018, Compound I-82)
Show SMILES COCCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H22FN5O3/c1-34-10-11-35-24-14-22(18-2-5-20(27)6-3-18)31-23-13-19(4-7-21(23)24)26(33)28-15-17-8-9-32-25(12-17)29-16-30-32/h2-9,12-14,16H,10-11,15H2,1H3,(H,28,33)
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MMDB

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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair