BDBM398508 (rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl]{2-[(1-methoxybutan-2-yl)amino]pyrimidin-5-yl}methanone::US10323020, Example 2::US10323020, Example 3

SMILES: CCC(COC)Nc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2ccc(F)cc2C1

InChI Key: InChIKey=IPQNIVVBRMLNAV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 398508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM398508 ((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...) Show SMILES CCC(COC)Nc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2ccc(F)cc2C1 Show InChI InChI=1S/C24H32FN5O2/c1-3-21(16-32-2)28-24-26-13-19(14-27-24)23(31)29-10-7-22(8-11-29)30-9-6-17-4-5-20(25)12-18(17)15-30/h4-5,12-14,21-22H,3,6-11,15-16H2,1-2H3,(H,26,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...				Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803
					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM398508 ((rac)-[4-(7-Fluoro-3,4-dihydroisoquinolin-2(1H)-yl...) Show SMILES CCC(COC)Nc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2ccc(F)cc2C1 Show InChI InChI=1S/C24H32FN5O2/c1-3-21(16-32-2)28-24-26-13-19(14-27-24)23(31)29-10-7-22(8-11-29)30-9-6-17-4-5-20(25)12-18(17)15-30/h4-5,12-14,21-22H,3,6-11,15-16H2,1-2H3,(H,26,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description Antagonism against the adrenoreceptor α1A was tested using a recombinant human α1A receptor CHO cell line which additionally also recombina...				Bioorg Med Chem Lett 19: 3344-7 (2009) BindingDB Entry DOI: 10.7270/Q2PN9803
					More data for this Ligand-Target Pair