BDBM400495 US10695337, Example 251::US9999619, Example 251
SMILES: Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
InChI Key: InChIKey=CTKQRINFSGLLTR-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
JAK1 (aa 837-1142) (Homo sapiens (Human)) | BDBM400495 (US10695337, Example 251 | US9999619, Example 251) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi... | Bioorg Med Chem 16: 4883-907 (2008) BindingDB Entry DOI: 10.7270/Q2C82CNM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (aa 828-1132) (Homo sapiens (Human)) | BDBM400495 (US10695337, Example 251 | US9999619, Example 251) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba... | US Patent US10695337 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK1 (aa 837-1142) (Homo sapiens (Human)) | BDBM400495 (US10695337, Example 251 | US9999619, Example 251) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba... | US Patent US10695337 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK2 (aa 828-1132) (Homo sapiens (Human)) | BDBM400495 (US10695337, Example 251 | US9999619, Example 251) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi... | Bioorg Med Chem 16: 4883-907 (2008) BindingDB Entry DOI: 10.7270/Q2C82CNM | |||||||||||
More data for this Ligand-Target Pair |