BDBM402034 5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 144::US10973817, Example 144
SMILES: COc1cc(CC2CCN(CC2)C(C)C)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
InChI Key: InChIKey=OPIMETSJAZZWRC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM402034 (5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl]-2-metho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
SENTINEL ONCOLOGY LIMITED US Patent | Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co... | US Patent US10973817 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM402034 (5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl]-2-metho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM-MRL Rome | Assay Description Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou... | J Med Chem 52: 5217-27 (2009) BindingDB Entry DOI: 10.7270/Q2NK3HCN | |||||||||||
More data for this Ligand-Target Pair |