null

SMILES: Cc1ccc(CNC(=O)c2cn(CC(F)CCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1

InChI Key: InChIKey=CWNSLOYUGOTDOA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 405086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405086 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES Cc1ccc(CNC(=O)c2cn(CC(F)CCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1 Show InChI InChI=1S/C25H25F4N9O3/c1-16-5-6-18(11-30-16)12-32-24(40)22-15-38(36-34-22)13-19(26)7-8-37-14-21(33-35-37)23(39)31-10-17-3-2-4-20(9-17)41-25(27,28)29/h2-6,9,11,14-15,19H,7-8,10,12-13H2,1H3,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76GP
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405086 (1-{2-fluoro-4-[4-({[3- (trifluoromethoxy)phenyl]me...) Show SMILES Cc1ccc(CNC(=O)c2cn(CC(F)CCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1 Show InChI InChI=1S/C25H25F4N9O3/c1-16-5-6-18(11-30-16)12-32-24(40)22-15-38(36-34-22)13-19(26)7-8-37-14-21(33-35-37)23(39)31-10-17-3-2-4-20(9-17)41-25(27,28)29/h2-6,9,11,14-15,19H,7-8,10,12-13H2,1H3,(H,31,39)(H,32,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair