BDBM406783 N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine::US10336761, Example 66

SMILES: FC(F)c1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cccn2n1

InChI Key: InChIKey=YYGMHSIWGFBSMJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406783   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type II (Homo sapiens (Human))	BDBM406783 (N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrr...) Show SMILES FC(F)c1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H10F4N6/c18-9-3-4-12(23-14(9)15(20)21)16-25-17(13-2-1-7-27(13)26-16)24-11-5-6-22-8-10(11)19/h1-8,15H,(H,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406783 (N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrr...) Show SMILES FC(F)c1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H10F4N6/c18-9-3-4-12(23-14(9)15(20)21)16-25-17(13-2-1-7-27(13)26-16)24-11-5-6-22-8-10(11)19/h1-8,15H,(H,22,24,25,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair