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SMILES: CC(C)(NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1)c1ccccn1

InChI Key: InChIKey=OSXBIOFAAZPBTB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-2 (Homo sapiens (Human))	BDBM407017 (3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)...) Show SMILES CC(C)(NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C25H23FN8/c1-25(2,21-8-4-6-12-29-21)30-15-17-10-14-34-22(17)24(31-19-9-13-27-16-18(19)26)32-23(33-34)20-7-3-5-11-28-20/h3-14,16,30H,15H2,1-2H3,(H,27,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407017 (3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)...) Show SMILES CC(C)(NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C25H23FN8/c1-25(2,21-8-4-6-12-29-21)30-15-17-10-14-34-22(17)24(31-19-9-13-27-16-18(19)26)32-23(33-34)20-7-3-5-11-28-20/h3-14,16,30H,15H2,1-2H3,(H,27,31,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair