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SMILES: Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC3CN(Cc4ccc(cc4)C#N)CCC23)cc1

InChI Key: InChIKey=NQUWUUOUBGGZER-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 409010   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))		BDBM409010
PNG
(4-((2-(5-(4-(4-fluorobenzyl)piperazine-1- carbonyl...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC3CN(Cc4ccc(cc4)C#N)CCC23)cc1
Show InChI InChI=1S/C32H35FN6O/c33-29-8-5-26(6-9-29)21-36-15-17-38(18-16-36)32(40)27-7-10-31(35-20-27)39-14-11-28-23-37(13-12-30(28)39)22-25-3-1-24(19-34)2-4-25/h1-10,20,28,30H,11-18,21-23H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US10377742 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R22
More data for this
Ligand-Target Pair