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SMILES: Fc1ccc(F)c(c1)[C@H]1C[C@@H](CN1c1ccn2ncc(C#N)c2n1)C#N

InChI Key: InChIKey=GUHRRWWDOFQWKH-BDJLRTHQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410188   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410188 (5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidi...) Show SMILES Fc1ccc(F)c(c1)[C@H]1C[C@@H](CN1c1ccn2ncc(C#N)c2n1)C#N |r| Show InChI InChI=1S/C18H12F2N6/c19-13-1-2-15(20)14(6-13)16-5-11(7-21)10-25(16)17-3-4-26-18(24-17)12(8-22)9-23-26/h1-4,6,9,11,16H,5,10H2/t11-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410188 (5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidi...) Show SMILES Fc1ccc(F)c(c1)[C@H]1C[C@@H](CN1c1ccn2ncc(C#N)c2n1)C#N |r| Show InChI InChI=1S/C18H12F2N6/c19-13-1-2-15(20)14(6-13)16-5-11(7-21)10-25(16)17-3-4-26-18(24-17)12(8-22)9-23-26/h1-4,6,9,11,16H,5,10H2/t11-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair