BDBM410198 US10370379, Compound 15

SMILES: NC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1nc2c(cnn2cc1F)C#N

InChI Key: InChIKey=ZILGMLTVSJMUDM-DZGCQCFKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410198 (US10370379, Compound 15) Show SMILES NC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1nc2c(cnn2cc1F)C#N |r| Show InChI InChI=1S/C18H13F3N6O/c19-12-2-9(1-10(3-12)16(23)28)15-4-13(20)7-26(15)18-14(21)8-27-17(25-18)11(5-22)6-24-27/h1-3,6,8,13,15H,4,7H2,(H2,23,28)/t13-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair