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SMILES: Fc1ccc2NC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3

InChI Key: InChIKey=BHVIDIBBALJGIR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410703   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM410703
PNG
(US10377772, Compound N4)
Show SMILES Fc1ccc2NC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3 |(4.62,1.74,;3.85,.41,;4.62,-.93,;3.85,-2.26,;2.31,-2.26,;1.44,-3.76,;-.86,-3.76,;-2.2,-4.53,;-3.53,-3.76,;-3.53,-2.22,;-2.2,-1.45,;-.86,-2.22,;-4.62,-1.13,;-3.53,-.04,;-3.93,1.45,;-2.59,2.22,;-2.59,3.76,;-1.26,4.53,;.07,3.76,;1.54,4.23,;2.44,2.99,;1.54,1.74,;2.31,.41,;1.54,-.93,;.07,2.22,;-1.26,1.45,)|
Show InChI InChI=1S/C19H21FN6/c20-17-2-1-14-11-15(17)16-12-22-26-9-5-18(24-19(16)26)21-6-10-25-7-3-13(23-14)4-8-25/h1-2,5,9,11-13,23H,3-4,6-8,10H2,(H,21,24)
PDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Oncodesign S.A.

US Patent


Assay Description
The inhibition of LRRK2 kinase was assessed using LRRK2 recombinant protein in an in vitro peptide-based kinase assay.ProtocolA radiometric protein k...

US Patent US10377772 (2019)


BindingDB Entry DOI: 10.7270/Q2251MJZ
More data for this
Ligand-Target Pair