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SMILES: CN1CCN2CCCC[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23

InChI Key: InChIKey=HPILAAOWUMFGOE-HNNXBMFYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410718   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM410718
PNG
(US10377772, Compound N19)
Show SMILES CN1CCN2CCCC[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|
Show InChI InChI=1S/C21H24FN5O/c1-25-10-11-26-8-3-2-4-15(26)14-28-16-5-6-19(22)17(12-16)18-13-23-27-9-7-20(25)24-21(18)27/h5-7,9,12-13,15H,2-4,8,10-11,14H2,1H3/t15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Oncodesign S.A.

US Patent


Assay Description
The inhibition of LRRK2 kinase was assessed using LRRK2 recombinant protein in an in vitro peptide-based kinase assay.ProtocolA radiometric protein k...

US Patent US10377772 (2019)


BindingDB Entry DOI: 10.7270/Q2251MJZ
More data for this
Ligand-Target Pair