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SMILES: Fc1ccc2OC[C@H]3CN4CCC[C@@H]4CN3CCNc3ccn4ncc(-c1c2)c4n3

InChI Key: InChIKey=KKPWTNMTBVMCGZ-HZPDHXFCSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410729   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM410729
PNG
(US10377772, Compound N30)
Show SMILES Fc1ccc2OC[C@H]3CN4CCC[C@@H]4CN3CCNc3ccn4ncc(-c1c2)c4n3 |r|
Show InChI InChI=1S/C22H25FN6O/c23-20-4-3-17-10-18(20)19-11-25-29-8-5-21(26-22(19)29)24-6-9-28-12-15-2-1-7-27(15)13-16(28)14-30-17/h3-5,8,10-11,15-16H,1-2,6-7,9,12-14H2,(H,24,26)/t15-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Oncodesign S.A.

US Patent


Assay Description
The inhibition of LRRK2 kinase was assessed using LRRK2 recombinant protein in an in vitro peptide-based kinase assay.ProtocolA radiometric protein k...

US Patent US10377772 (2019)


BindingDB Entry DOI: 10.7270/Q2251MJZ
More data for this
Ligand-Target Pair