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SMILES: Fc1ccc2OC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3

InChI Key: InChIKey=GOUWYTASGRZKFS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410732   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM410732
PNG
(US10377772, Compound N33)
Show SMILES Fc1ccc2OC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3 |(5.09,1.17,;4,.08,;4.4,-1.41,;3.31,-2.5,;1.82,-2.1,;.73,-3.19,;-2.51,-4.35,;-4,-4.75,;-5.09,-3.66,;-4.69,-2.18,;-3.2,-1.78,;-2.11,-2.87,;-4.69,-.64,;-3.35,.13,;-3.35,1.67,;-2.02,2.44,;-2.02,3.98,;-.69,4.75,;.65,3.98,;2.11,4.46,;3.02,3.21,;2.11,1.97,;2.51,.48,;1.42,-.61,;.65,2.44,;-.69,1.67,)|
Show InChI InChI=1S/C19H20FN5O/c20-17-2-1-14-11-15(17)16-12-22-25-9-5-18(23-19(16)25)21-6-10-24-7-3-13(26-14)4-8-24/h1-2,5,9,11-13H,3-4,6-8,10H2,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Oncodesign S.A.

US Patent


Assay Description
The inhibition of LRRK2 kinase was assessed using LRRK2 recombinant protein in an in vitro peptide-based kinase assay.ProtocolA radiometric protein k...

US Patent US10377772 (2019)


BindingDB Entry DOI: 10.7270/Q2251MJZ
More data for this
Ligand-Target Pair