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SMILES: Fc1ccc2OC[C@@H]3CCCN3CCNc3ccc4ncc(-c1c2)n4n3

InChI Key: InChIKey=OXHQVJMPBDJYRE-ZDUSSCGKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410751   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM410751
PNG
(US10377772, Compound N52)
Show SMILES Fc1ccc2OC[C@@H]3CCCN3CCNc3ccc4ncc(-c1c2)n4n3 |r|
Show InChI InChI=1S/C19H20FN5O/c20-16-4-3-14-10-15(16)17-11-22-19-6-5-18(23-25(17)19)21-7-9-24-8-1-2-13(24)12-26-14/h3-6,10-11,13H,1-2,7-9,12H2,(H,21,23)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Oncodesign S.A.

US Patent


Assay Description
The inhibition of LRRK2 kinase was assessed using LRRK2 recombinant protein in an in vitro peptide-based kinase assay.ProtocolA radiometric protein k...

US Patent US10377772 (2019)


BindingDB Entry DOI: 10.7270/Q2251MJZ
More data for this
Ligand-Target Pair