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BDBM412682 US10399979, Compound 17f

SMILES: COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC

InChI Key: InChIKey=USKNKBXRDISSHA-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 412682   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
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n/an/a 11.5n/an/an/an/an/an/a



Purdue Research Foundation

US Patent


Assay Description
Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...


US Patent US10399979 (2019)


BindingDB Entry DOI: 10.7270/Q29G5Q52
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
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n/an/a 14.7n/an/an/an/an/an/a



Purdue Research Foundation

US Patent


Assay Description
Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...


US Patent US10399979 (2019)


BindingDB Entry DOI: 10.7270/Q29G5Q52
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

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n/an/a 18.3n/an/an/an/an/an/a



Purdue Research Foundation

US Patent


Assay Description
Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...


US Patent US10399979 (2019)


BindingDB Entry DOI: 10.7270/Q29G5Q52
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

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n/an/a 15n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method


J Med Chem 61: 10440-10462 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00510
BindingDB Entry DOI: 10.7270/Q2BR8VVW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

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Article
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n/an/a 18n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method


J Med Chem 61: 10440-10462 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00510
BindingDB Entry DOI: 10.7270/Q2BR8VVW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

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Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method


J Med Chem 61: 10440-10462 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00510
BindingDB Entry DOI: 10.7270/Q2BR8VVW
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

KEGG

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antibodypedia
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Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method


J Med Chem 61: 10440-10462 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00510
BindingDB Entry DOI: 10.7270/Q2BR8VVW
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM412682
PNG
(US10399979, Compound 17f)
Show SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCNCC3)c(=O)c2cc1OC
Show InChI InChI=1S/C21H22N4O3/c1-27-17-9-14-15(10-18(17)28-2)21(26)25(12-3-6-22-7-4-12)19-13-5-8-23-20(13)24-11-16(14)19/h5,8-12,22H,3-4,6-7H2,1-2H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 32.4n/an/an/an/an/an/a



Purdue Research Foundation

US Patent


Assay Description
Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...


US Patent US10399979 (2019)


BindingDB Entry DOI: 10.7270/Q29G5Q52
More data for this
Ligand-Target Pair