null
SMILES: FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1
InChI Key: InChIKey=JKKVCWQINKOSMZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM412738 (2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myer Squibb Company US Patent | Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec... | US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM412738 (2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myer Squibb Company US Patent | Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec... | US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N | |||||||||||
More data for this Ligand-Target Pair |