null

SMILES: O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12

InChI Key: InChIKey=DBLBOZLZPCJKAH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 419791   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM419791 (US10464919, Example 129) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C22H23N7O/c23-11-16-12-26-20(13-25-16)29-8-6-28(7-9-29)14-15-3-4-17-19(10-15)27-22(30)18-2-1-5-24-21(17)18/h3-4,10,12-13,24H,1-2,5-9,14H2,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.28	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Activated CDC42 kinase 1 (Homo sapiens (Human))	BDBM419791 (US10464919, Example 129) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C22H23N7O/c23-11-16-12-26-20(13-25-16)29-8-6-28(7-9-29)14-15-3-4-17-19(10-15)27-22(30)18-2-1-5-24-21(17)18/h3-4,10,12-13,24H,1-2,5-9,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.65	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419791 (US10464919, Example 129) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C22H23N7O/c23-11-16-12-26-20(13-25-16)29-8-6-28(7-9-29)14-15-3-4-17-19(10-15)27-22(30)18-2-1-5-24-21(17)18/h3-4,10,12-13,24H,1-2,5-9,14H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.56	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair