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SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C

InChI Key: InChIKey=HGJRNYLCDLBCIK-LBPRGKRZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420101   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420101
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N(C)C |r|
Show InChI InChI=1S/C21H22N6O2S/c1-26(2)21(28)12-4-5-14-17(8-12)30-20-18(14)19(22-11-23-20)25-15-9-13-6-7-24-27(13)10-16(15)29-3/h6-7,9-12H,4-5,8H2,1-3H3,(H,22,23,25)/t12-/m0/s1
PDB

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US Patent
n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair