BindingDB logo
myBDB logout

null

SMILES: CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21

InChI Key: InChIKey=CNVCZSCFVUDWJF-NUEKZKHPSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420184   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420184
PNG
((7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino...)
Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r,TLB:0:1:7.6:4,8:7:2.1:4|
Show InChI InChI=1S/C24H24ClN7OS/c1-30-9-16-7-15(30)10-31(16)24(33)13-2-3-17-20(6-13)34-23-21(17)22(26-12-27-23)29-19-8-14-4-5-28-32(14)11-18(19)25/h4-5,8,11-13,15-16H,2-3,6-7,9-10H2,1H3,(H,26,27,29)/t13-,15+,16+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair