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SMILES: CNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21

InChI Key: InChIKey=DXPVFTASDLJHRU-NSHDSACASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420192   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420192
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES CNC(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r|
Show InChI InChI=1S/C20H20N6O2S/c1-21-19(27)11-3-4-13-16(7-11)29-20-17(13)18(22-10-23-20)25-14-8-12-5-6-24-26(12)9-15(14)28-2/h5-6,8-11H,3-4,7H2,1-2H3,(H,21,27)(H,22,23,25)/t11-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 5n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair