BDBM420312 5-Bromo-2-methyl-3-[(1-methylethyl)amino]-N-{[6-methyl-2-oxo-4-(phenylmethyl)-1,2-dihydro-3-pyridinyl]methyl}benzamide::US10478426, Example 4

SMILES: CC(C)Nc1cc(Br)cc(C(=O)NCc2c(Cc3ccccc3)cc(C)[nH]c2=O)c1C

InChI Key: InChIKey=SNUWAWGCYPMRAZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human))	BDBM420312 (5-Bromo-2-methyl-3-[(1-methylethyl)amino]-N-{[6-me...) Show SMILES CC(C)Nc1cc(Br)cc(C(=O)NCc2c(Cc3ccccc3)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H28BrN3O2/c1-15(2)28-23-13-20(26)12-21(17(23)4)24(30)27-14-22-19(10-16(3)29-25(22)31)11-18-8-6-5-7-9-18/h5-10,12-13,15,28H,11,14H2,1-4H3,(H,27,30)(H,29,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE LLC US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US10478426 (2019) BindingDB Entry DOI: 10.7270/Q2M61NMK
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