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SMILES: Nc1ncc(nc1-c1nnc(o1)-c1ccccc1)-n1cccc1C#N

InChI Key: InChIKey=QQIFDSPHOZKKMQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 420764   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM420764 (1-[5-amino-6-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazi...) Show SMILES Nc1ncc(nc1-c1nnc(o1)-c1ccccc1)-n1cccc1C#N Show InChI InChI=1S/C17H11N7O/c18-9-12-7-4-8-24(12)13-10-20-15(19)14(21-13)17-23-22-16(25-17)11-5-2-1-3-6-11/h1-8,10H,(H2,19,20)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...				US Patent US10961232 (2021) BindingDB Entry DOI: 10.7270/Q2VT1W6G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM420764 (1-[5-amino-6-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazi...) Show SMILES Nc1ncc(nc1-c1nnc(o1)-c1ccccc1)-n1cccc1C#N Show InChI InChI=1S/C17H11N7O/c18-9-12-7-4-8-24(12)13-10-20-15(19)14(21-13)17-23-22-16(25-17)11-5-2-1-3-6-11/h1-8,10H,(H2,19,20)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...				US Patent US10479784 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WVD
					More data for this Ligand-Target Pair