null

SMILES: Cc1cc(C)cc(Cn2c3ccc(cc3n(C)c2=O)S(=O)(=O)NC2(C)CC2)c1

InChI Key: InChIKey=OACQRWADBBXDIX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421458 (US10508086, Example 49 | US10995073, Example 49) Show SMILES Cc1cc(C)cc(Cn2c3ccc(cc3n(C)c2=O)S(=O)(=O)NC2(C)CC2)c1 Show InChI InChI=1S/C21H25N3O3S/c1-14-9-15(2)11-16(10-14)13-24-18-6-5-17(12-19(18)23(4)20(24)25)28(26,27)22-21(3)7-8-21/h5-6,9-12,22H,7-8,13H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.07E+3	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421458 (US10508086, Example 49 | US10995073, Example 49) Show SMILES Cc1cc(C)cc(Cn2c3ccc(cc3n(C)c2=O)S(=O)(=O)NC2(C)CC2)c1 Show InChI InChI=1S/C21H25N3O3S/c1-14-9-15(2)11-16(10-14)13-24-18-6-5-17(12-19(18)23(4)20(24)25)28(26,27)22-21(3)7-8-21/h5-6,9-12,22H,7-8,13H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.07E+3	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair