null

SMILES: Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1

InChI Key: InChIKey=ITQSVBWAGTUWAZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 421584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair