BDBM421621 US10508086, Example 211::US10995073, Example 211

SMILES: CC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(o3)C(F)F)c(=O)n(CCF)c2cc1F

InChI Key: InChIKey=MYXJLFXFMPSEMX-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 421621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421621 (US10508086, Example 211 | US10995073, Example 211) Show SMILES CC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(o3)C(F)F)c(=O)n(CCF)c2cc1F Show InChI InChI=1S/C16H15F4N5O4S/c1-16(2-3-16)23-30(27,28)11-7-10-9(6-8(11)18)24(5-4-17)15(26)25(10)14-22-21-13(29-14)12(19)20/h6-7,12,23H,2-5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	401	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421621 (US10508086, Example 211 | US10995073, Example 211) Show SMILES CC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(o3)C(F)F)c(=O)n(CCF)c2cc1F Show InChI InChI=1S/C16H15F4N5O4S/c1-16(2-3-16)23-30(27,28)11-7-10-9(6-8(11)18)24(5-4-17)15(26)25(10)14-22-21-13(29-14)12(19)20/h6-7,12,23H,2-5H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021)
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421621 (US10508086, Example 211 | US10995073, Example 211) Show SMILES CC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(o3)C(F)F)c(=O)n(CCF)c2cc1F Show InChI InChI=1S/C16H15F4N5O4S/c1-16(2-3-16)23-30(27,28)11-7-10-9(6-8(11)18)24(5-4-17)15(26)25(10)14-22-21-13(29-14)12(19)20/h6-7,12,23H,2-5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	401	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10995073 (2021)
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421621 (US10508086, Example 211 | US10995073, Example 211) Show SMILES CC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(o3)C(F)F)c(=O)n(CCF)c2cc1F Show InChI InChI=1S/C16H15F4N5O4S/c1-16(2-3-16)23-30(27,28)11-7-10-9(6-8(11)18)24(5-4-17)15(26)25(10)14-22-21-13(29-14)12(19)20/h6-7,12,23H,2-5H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair