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SMILES: FCC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(s3)C(F)F)c(=O)n(CC#C)c2cc1F

InChI Key: InChIKey=URTWIVPGEQNNEZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 421623   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421623 (US10508086, Example 213 | US10995073, Example 213) Show SMILES FCC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(s3)C(F)F)c(=O)n(CC#C)c2cc1F Show InChI InChI=1S/C17H13F4N5O3S2/c1-2-5-25-10-6-9(19)12(31(28,29)24-17(8-18)3-4-17)7-11(10)26(16(25)27)15-23-22-14(30-15)13(20)21/h1,6-7,13,24H,3-5,8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421623 (US10508086, Example 213 | US10995073, Example 213) Show SMILES FCC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(s3)C(F)F)c(=O)n(CC#C)c2cc1F Show InChI InChI=1S/C17H13F4N5O3S2/c1-2-5-25-10-6-9(19)12(31(28,29)24-17(8-18)3-4-17)7-11(10)26(16(25)27)15-23-22-14(30-15)13(20)21/h1,6-7,13,24H,3-5,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021)
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421623 (US10508086, Example 213 | US10995073, Example 213) Show SMILES FCC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(s3)C(F)F)c(=O)n(CC#C)c2cc1F Show InChI InChI=1S/C17H13F4N5O3S2/c1-2-5-25-10-6-9(19)12(31(28,29)24-17(8-18)3-4-17)7-11(10)26(16(25)27)15-23-22-14(30-15)13(20)21/h1,6-7,13,24H,3-5,8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10995073 (2021)
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421623 (US10508086, Example 213 | US10995073, Example 213) Show SMILES FCC1(CC1)NS(=O)(=O)c1cc2n(-c3nnc(s3)C(F)F)c(=O)n(CC#C)c2cc1F Show InChI InChI=1S/C17H13F4N5O3S2/c1-2-5-25-10-6-9(19)12(31(28,29)24-17(8-18)3-4-17)7-11(10)26(16(25)27)15-23-22-14(30-15)13(20)21/h1,6-7,13,24H,3-5,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair