BDBM421865 (S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-2-(3-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazol-5-yl)-2,7-diazaspiro[4.4]nonan-1-one::US10493060, Example 28::US10525036, Example 28
SMILES: Fc1cnc(nc1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccnc(c4)C(F)(F)F)c3c2)C1
InChI Key:
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 3 (Homo sapiens (Human)) | BDBM421865![]() ((S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Recurium IP Holdings, LLC US Patent | Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as... | US Patent US10493060 (2019) BindingDB Entry DOI: 10.7270/Q2SQ92R3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM421865![]() ((S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Recurium IP Holdings, LLC US Patent | Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as... | US Patent US10525036 (2020) BindingDB Entry DOI: 10.7270/Q26Q20N0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 3 (Homo sapiens (Human)) | BDBM421865![]() ((S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Recurium IP Holdings, LLC US Patent | Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as... | US Patent US10525036 (2020) BindingDB Entry DOI: 10.7270/Q26Q20N0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM421865![]() ((S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Recurium IP Holdings, LLC US Patent | Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as... | US Patent US10493060 (2019) BindingDB Entry DOI: 10.7270/Q2SQ92R3 | |||||||||||
More data for this Ligand-Target Pair |