BDBM421866 (S)-2-(3-(4-Fluorophenyl)-1H-indazol-5-yl)-7-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-2,7-diazaspiro[4.4]nonan-1-one::US10493060, Example 29::US10525036, Example 29

SMILES: Cn1cnc(n1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 421866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM421866 ((S)-2-(3-(4-Fluorophenyl)-1H-indazol-5-yl)-7-(2-(4...) Show SMILES Cn1cnc(n1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1 |r,t:14| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Recurium IP Holdings, LLC US Patent					Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...				US Patent US10493060 (2019) BindingDB Entry DOI: 10.7270/Q2SQ92R3
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM421866 ((S)-2-(3-(4-Fluorophenyl)-1H-indazol-5-yl)-7-(2-(4...) Show SMILES Cn1cnc(n1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1 |r,t:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Recurium IP Holdings, LLC US Patent					Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...				US Patent US10525036 (2020) BindingDB Entry DOI: 10.7270/Q26Q20N0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM421866 ((S)-2-(3-(4-Fluorophenyl)-1H-indazol-5-yl)-7-(2-(4...) Show SMILES Cn1cnc(n1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1 |r,t:14| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Recurium IP Holdings, LLC US Patent					Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...				US Patent US10525036 (2020) BindingDB Entry DOI: 10.7270/Q26Q20N0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM421866 ((S)-2-(3-(4-Fluorophenyl)-1H-indazol-5-yl)-7-(2-(4...) Show SMILES Cn1cnc(n1)-c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)C1 |r,t:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Recurium IP Holdings, LLC US Patent					Assay Description Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...				US Patent US10493060 (2019) BindingDB Entry DOI: 10.7270/Q2SQ92R3
					More data for this Ligand-Target Pair