Found 4 hits for monomerid = 422120 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apelin receptor
(Homo sapiens (Human)) | BDBM422120
![PNG](/data/jpeg/tenK42/BindingDB_422120.png) (1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-3-...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1CCC(C)C)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1 |(-6.67,-2.31,;-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-4,2.31,;-4,.77,;-5.33,,;-6.67,.77,;-8,,;-9.34,.77,;-8,-1.54,;,3.08,;-.77,4.41,;.77,4.41,;1.33,2.31,;1.33,.77,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;5.33,,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;9.34,-2.31,;8,,;6.67,.77,)| Show InChI InChI=1S/C28H28FN3O6S/c1-17(2)8-15-24-31-27(33)26(28(34)32(24)25-21(37-3)6-5-7-22(25)38-4)39(35,36)20-12-9-18(10-13-20)19-11-14-23(29)30-16-19/h5-7,9-14,16-17,34H,8,15H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ... |
US Patent US10508104 (2019)
BindingDB Entry DOI: 10.7270/Q21838WS |
More data for this Ligand-Target Pair | |
Apelin receptor
(Mus musculus) | BDBM422120
![PNG](/data/jpeg/tenK42/BindingDB_422120.png) (1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-3-...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1CCC(C)C)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1 |(-6.67,-2.31,;-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-4,2.31,;-4,.77,;-5.33,,;-6.67,.77,;-8,,;-9.34,.77,;-8,-1.54,;,3.08,;-.77,4.41,;.77,4.41,;1.33,2.31,;1.33,.77,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;5.33,,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;9.34,-2.31,;8,,;6.67,.77,)| Show InChI InChI=1S/C28H28FN3O6S/c1-17(2)8-15-24-31-27(33)26(28(34)32(24)25-21(37-3)6-5-7-22(25)38-4)39(35,36)20-12-9-18(10-13-20)19-11-14-23(29)30-16-19/h5-7,9-14,16-17,34H,8,15H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM422120
![PNG](/data/jpeg/tenK42/BindingDB_422120.png) (1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-3-...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1CCC(C)C)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1 |(-6.67,-2.31,;-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-4,2.31,;-4,.77,;-5.33,,;-6.67,.77,;-8,,;-9.34,.77,;-8,-1.54,;,3.08,;-.77,4.41,;.77,4.41,;1.33,2.31,;1.33,.77,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;5.33,,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;9.34,-2.31,;8,,;6.67,.77,)| Show InChI InChI=1S/C28H28FN3O6S/c1-17(2)8-15-24-31-27(33)26(28(34)32(24)25-21(37-3)6-5-7-22(25)38-4)39(35,36)20-12-9-18(10-13-20)19-11-14-23(29)30-16-19/h5-7,9-14,16-17,34H,8,15H2,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM422120
![PNG](/data/jpeg/tenK42/BindingDB_422120.png) (1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-3-...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1CCC(C)C)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1 |(-6.67,-2.31,;-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-4,2.31,;-4,.77,;-5.33,,;-6.67,.77,;-8,,;-9.34,.77,;-8,-1.54,;,3.08,;-.77,4.41,;.77,4.41,;1.33,2.31,;1.33,.77,;2.67,,;4,.77,;4,2.31,;2.67,3.08,;5.33,,;5.33,-1.54,;6.67,-2.31,;8,-1.54,;9.34,-2.31,;8,,;6.67,.77,)| Show InChI InChI=1S/C28H28FN3O6S/c1-17(2)8-15-24-31-27(33)26(28(34)32(24)25-21(37-3)6-5-7-22(25)38-4)39(35,36)20-12-9-18(10-13-20)19-11-14-23(29)30-16-19/h5-7,9-14,16-17,34H,8,15H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |