BDBM423283 US10501451, Example 10, P-1::US10501451, Example 10, P-2::US10954225, Example 10,P-2

SMILES: Cc1ccc(CN2OCC(N3CCN(CC3)c3ccc(O)cn3)C2=O)cc1

InChI Key: InChIKey=PSXAMPZZTNVYRP-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423283   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423283 (US10501451, Example 10, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCC(N3CCN(CC3)c3ccc(O)cn3)C2=O)cc1 Show InChI InChI=1S/C20H24N4O3/c1-15-2-4-16(5-3-15)13-24-20(26)18(14-27-24)22-8-10-23(11-9-22)19-7-6-17(25)12-21-19/h2-7,12,18,25H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423283 (US10501451, Example 10, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCC(N3CCN(CC3)c3ccc(O)cn3)C2=O)cc1 Show InChI InChI=1S/C20H24N4O3/c1-15-2-4-16(5-3-15)13-24-20(26)18(14-27-24)22-8-10-23(11-9-22)19-7-6-17(25)12-21-19/h2-7,12,18,25H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423283 (US10501451, Example 10, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCC(N3CCN(CC3)c3ccc(O)cn3)C2=O)cc1 Show InChI InChI=1S/C20H24N4O3/c1-15-2-4-16(5-3-15)13-24-20(26)18(14-27-24)22-8-10-23(11-9-22)19-7-6-17(25)12-21-19/h2-7,12,18,25H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423283 (US10501451, Example 10, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCC(N3CCN(CC3)c3ccc(O)cn3)C2=O)cc1 Show InChI InChI=1S/C20H24N4O3/c1-15-2-4-16(5-3-15)13-24-20(26)18(14-27-24)22-8-10-23(11-9-22)19-7-6-17(25)12-21-19/h2-7,12,18,25H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair