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SMILES: CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O

InChI Key: InChIKey=QIMOBLHMKZLPIE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 423312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H](+)8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 30 mins by liquid scintillation counting method				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112709 BindingDB Entry DOI: 10.7270/Q2XK8K6M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	179	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting method				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112709 BindingDB Entry DOI: 10.7270/Q2XK8K6M
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	391	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting method				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112709 BindingDB Entry DOI: 10.7270/Q2XK8K6M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NHWA PHARMA. CORPORATION US Patent					Assay Description 5-HT1A: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed ...				US Patent US10501452 (2019) BindingDB Entry DOI: 10.7270/Q2BK1FR6
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NHWA PHARMA. CORPORATION US Patent					Assay Description D2:Procedures(1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were m...				US Patent US10501452 (2019) BindingDB Entry DOI: 10.7270/Q2BK1FR6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM423312 (US10501452, Compound 18) Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ccccc3Cl)cc2C1=O Show InChI InChI=1S/C23H28ClN3O2/c1-25-11-9-18-7-8-19(17-20(18)23(25)28)29-16-4-10-26-12-14-27(15-13-26)22-6-3-2-5-21(22)24/h2-3,5-8,17H,4,9-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NHWA PHARMA. CORPORATION US Patent					Assay Description 5-HT2A:(1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...				US Patent US10501452 (2019) BindingDB Entry DOI: 10.7270/Q2BK1FR6
					More data for this Ligand-Target Pair