null
SMILES: CC(C)c1c([nH]c2ccc(nc12)N1CCNCC1)-c1cn2ncnc2c(C)c1C
InChI Key: InChIKey=XLLPHYRQYQABDZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 7.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM427564![]() (6-(3-isopropyl-5-(piperazin-1-yl)-1H-pyrrolo[3,2-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80 | |||||||||||
More data for this Ligand-Target Pair |