BDBM427568 N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-5-carboxamide::US10544143, Example 6::US10730877, Example 6

SMILES: CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1

InChI Key: InChIKey=MAULDPIIJDWSKW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 427568   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	625	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427568 (N-(2-(dimethylamino)ethyl)-N-ethyl-3-isopropyl-2-(...) Show SMILES CCN(CCN(C)C)C(=O)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 Show InChI InChI=1S/C25H33N7O2/c1-8-31(10-9-30(5)6)25(33)21-16(4)11-18-23(29-21)20(15(2)3)22(28-18)17-12-19(34-7)24-26-14-27-32(24)13-17/h11-15,28H,8-10H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair