Found 18 hits for monomerid = 427879 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
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antibodypedia
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| PC cid
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UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427879
(US10544143, Example 313 | US10544143, Example 320 ...)Show SMILES CCN(C)C1CCC(CC1)c1nc2c(C(C)C)c([nH]c2cc1C)-c1cc(OC)c2ncnn2c1 |(-9,.08,;-9,1.62,;-7.66,2.39,;-7.66,3.93,;-6.33,1.62,;-6.33,.08,;-5,-.69,;-3.66,.08,;-3.66,1.62,;-5,2.39,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;4.25,-1.46,;5.02,-.12,;6.56,-.12,;7.33,1.21,;8.87,1.21,;7.33,-1.46,;8.84,-1.78,;9,-3.31,;7.59,-3.93,;6.56,-2.79,;5.02,-2.79,)| Show InChI InChI=1S/C27H36N6O/c1-7-32(5)20-10-8-18(9-11-20)24-17(4)12-21-26(31-24)23(16(2)3)25(30-21)19-13-22(34-6)27-28-15-29-33(27)14-19/h12-16,18,20,30H,7-11H2,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
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